CALL FOR PAPERS Sex and Gender Differences in Renal Physiology Defective renal dopamine function and sodium-sensitive hypertension in adult ovariectomized Wistar rats: role of the cytochrome P-450 pathway

نویسندگان

  • Luis A. Di Ciano
  • Pablo J. Azurmendi
  • Cecilia Colombero
  • Gloria Levin
  • Elisabet M. Oddo
  • Elvira E. Arrizurieta
  • Susana Nowicki
  • Fernando R. Ibarra
چکیده

Luis A. Di Ciano, Pablo J. Azurmendi, Cecilia Colombero, Gloria Levin, Elisabet M. Oddo, Elvira E. Arrizurieta, Susana Nowicki, and Fernando R. Ibarra Instituto de Investigaciones Médicas A Lanari, Buenos Aires University, Buenos Aires, Argentina; Centro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)FEI-División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina; Departamento de Fisiología, Facultad de Medicina, Buenos Aires University, Buenos Aires, Argentina; and CONICET, Buenos Aires, Argentina

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Defective renal dopamine function and sodium-sensitive hypertension in adult ovariectomized Wistar rats: role of the cytochrome P-450 pathway.

We have previously shown that ovariectomy in adult Wistar rats under normal sodium (NS) intake results in an overexpression of the total Na(+)-K(+)-ATPase (NKA) α1-subunit (Di Ciano LA, Azurmendi PJ, Toledo JE, Oddo EM, Zotta E, Ochoa F, Arrizurieta EE, Ibarra FR. Clin Exp Hypertens 35: 475-483, 2013). Upon high sodium (HS) intake, ovariectomized (oVx) rats developed defective NKA phosphorylati...

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تاریخ انتشار 2015